Optimal weight loss pace on GLP-1 therapy
Clinical guidelines from AACE and the Obesity Medicine Association recommend 0.5–1.5 lbs (0.23–0.68 kg) per week as the optimal pace for sustainable weight loss during GLP-1 therapy. This range balances fat loss with preservation of lean muscle mass and reduces the risk of nutritional deficiencies.
Losses of 2–3+ lbs per week are considered rapid and carry increased risks. Accelerated weight loss is a known risk factor for cholesterol gallstone formation (the gallbladder can't empty properly when fat intake drops sharply). It also increases the rate of lean muscle loss — sometimes called "skinny fat" — and can accelerate facial fat loss, colloquially termed "Ozempic face".