What HbA1c measures
Haemoglobin A1c forms when glucose in the bloodstream attaches to haemoglobin in red blood cells. Since red blood cells live approximately 90–120 days, the proportion of glycated haemoglobin reflects average blood glucose over that period. Higher average glucose means more glycation and a higher A1c percentage.
A1c is weighted toward the most recent 4–6 weeks because newly formed red blood cells represent the most recently glycated fraction. A major illness, blood transfusion, or haemolytic anaemia can invalidate A1c as a measure of average glucose.